Brain and Cognitive Aging

Amos Pagin

I am a PhD candidate in Psychology at the University of Gothenburg, researching heterogeneity and resilience in late-life neurocognitive decline. My research aims to characterize patterns of brain and cognitive deterioration, and to identify factors that modulate these trajectories.

To study these questions, I build scalable pipelines for Bayesian modeling of longitudinal data, enabling comprehensive hypothesis testing across modalities (PET, MRI), brain regions, and cognitive domains. Read more ↓

Amos Pagin

About

I work in the Lövdén Lab and the ICON Lab, using longitudinal PET and MRI data from the COBRA prospective cohort study and the Lifebrain Consortium. My dissertation examines whether and how education moderates the relationship between brain change and cognitive decline in healthy older adults. I expect to defend in autumn 2026. Going forward, I am interested in extending these methods to preclinical Alzheimer's disease, integrating fluid biomarkers and tau/amyloid PET with longitudinal cognitive data to understand early neurodegenerative vulnerability.

In my current research, I build and apply computational pipelines for Bayesian structural equation modeling, often running hundreds of model specifications in batch. This enables exhaustive probabilistic modeling of brain-cognition associations across modalities, brain regions, cognitive domains, and model specifications, rather than selective testing of individual models. For an example, see this preprint.

school University of Gothenburg location_on Gothenburg, Sweden

News

Apr 2026

Accepted to the NIA-funded Advanced Psychometric Methods in Cognitive Aging Research (ΨMCA) workshop. Granlibakken, Lake Tahoe, CA (August 2026).

Mar 2026

Started development of semla, a Python package for structural equation modeling and latent variable analysis.

Jan 2026

Manuscript on dopamine D2 receptor loss, cognitive decline, and lifestyle factors under revision at Imaging Neuroscience.

Nov 2024

Half-time seminar completed. Department of Psychology, University of Gothenburg.

May 2024

Talk at the COBRA Project Retreat, Max Planck Institute for Human Development, Berlin.

Recent Publications

All Papers arrow_forward
2025 description

Five-Year Associations Among Dopamine D2-Like Receptor Loss, Cognitive Decline, and Lifestyle Factors in Healthy Older Adults

PET imaging from the COBRA study examining five-year associations among dopamine D2-like receptor loss, cognitive decline, and lifestyle factors.

Imaging Neuroscience Under Revision
2023 description

No Moderating Influence of Education on Changes in Hippocampus Volume and Memory

Multi-cohort study testing whether education moderates the link between hippocampal atrophy and memory decline.

Aging Brain Read Paper